Polynucleotides might sound like a mouthful, but at their core, they are simply long chains of smaller units called nucleotides. Think of nucleotides like pearls on a necklace—each pearl (a nucleotide) connects to form a chain (the polynucleotide). In biology, these chains are the building blocks of the genetic material found in all living organisms, namely DNA (deoxyribonucleic acid) and RNA (ribonucleic acid) and are essential for your skin tissues to function at their natural best.

When polynucleotides are administered (with small injections) into the skin, they break down into smaller nucleotides and provide any damaged genetic chains with the ingredients to fill in missing information. Essentially, you are adding more pearls back to a broken string of pearls, restoring its former glory.

This regenerative action results in improved skin cell signalling, which supports skin cell growth, reduces inflammation and enhances skin repair and rejuvenation.

Plinest Polynucleotides are derived form ethically sourced farmed Trout with HPT Technology, meaning there’s no trace of fish left in them – just DNA material that our skin recognises.

Polynucleotide injections are suitable for a range of skin types and ages, particularly for individuals dealing with:

• Early signs of aging

• Thinning crapey skin under the eyes

• Dehydrated, dull skin

• Mild to moderate laxity

• Minor scarring or uneven texture

Those with more advanced aging concerns may still benefit from PN therapy but often in combination with other treatments like fillers, lasers, or energy-based devices.

You will initially require 2-3 treatments spaced 3 weeks apart. Plinest Polynucleotides require ongoing maintenance with a single top-up treatment advised every 6 months. This will be discussed with your practitioner as it depends on your ageing, skin wrinkling/damage, and lifestyle.

Enhanced Skin Hydration

One of the most noticeable improvements following PN treatments is increased skin hydration. Polynucleotides have hygroscopic (water-attracting) properties, helping your skin retain more moisture. As a result:

• Skin feels softer, more supple

• Dry or dull areas appear more vibrant

• Fine lines associated with dehydration may be less visible

Improved Elasticity & Firmness

Polynucleotides work at the cellular level to support the skin’s natural regeneration process, promoting the production of collagen and elastin. This can:

• Strengthen the skin’s structure

• Give a firmer, “bouncier” texture

• Gradually improve sagging or laxity

Reduction in Fine Lines & Wrinkles

By stimulating fibroblasts (the cells that produce collagen) and aiding in tissue repair, polynucleotides help to smooth out fine lines:

• Subtle rejuvenation: Especially in areas prone to creasing (crow’s feet, forehead lines, nasolabial folds).

• Refined texture: Skin looks smoother and more even over time.

Brighter, More Even-Toned Skin

Many patients report an overall brightening of the complexion after a series of PN treatments. This is due to:

• Enhanced cellular turnover: Damaged or dull surface cells are replaced more quickly.

• Reduced inflammation: Polynucleotides can help calm irritation, which in turn may lessen redness or blotchiness.

Reduced Appearance of Scars

Because of their regenerative properties, polynucleotides can also improve the look of scars:

• Acne scars: The repair mechanisms help remodel scar tissue for a smoother surface.

• Post-surgical or trauma scars: Collagen-stimulating properties promote more unified healing.

Gradual, Natural-Looking Improvements

Unlike some aesthetic treatments that deliver instant but sometimes stark changes, polynucleotide therapies typically yield subtle, progressive results:

• Most people notice initial improvements—like increased hydration and radiance—within a few days.

• Firmer skin and softening of lines often become more apparent after a few weeks, as collagen production ramps up.

• Final results continue to refine for several months post-treatment.

Yes, every medical treatment carries some risks and these will be fully explained during consultation. However you may find it comforting to know that Plinest polynucleotides are generally considered low risk injectable treatments with the main side effects being that of potential bruises from the injection sites and mild swelling for 1-2 days. You may notice the product sitting under the skin during this time as little bumps. Many patients comment that it is barely noticeable, whereas some state it is defined for a few days, especially around the eyes or in thin-skinned individuals.

You may develop a bruise, and you may experience some swelling for 1-2 days after. You may notice the product sitting under the skin during this time. Many patients comment that it is barely noticeable, whereas some state it is defined for a few days, especially around the eyes.

You will most likely see results 4 weeks after the initial treatment. However it is important to complete the initial course of 2-3 treatments, three to four weeks apart, in order to fully see the benefits. You will see the final effects show around four to eight weeks after your final treatment.

Yes, and this will be fully discussed and written for you following your treatment. However it may be helpful to know the following:

• Do not massage the treatment area. The product will naturally diffuse to where it needs to go over 48 hours.

• Avoid physical strain and sports for 24 hours.

• Avoid having further cosmetic procedures for 48 hours.

• It is not recommended to have sauna or steamy bath for the first few days either.

• It’s best to stay out of the sun if any bruising or prolonged swelling occurs.

The effects of Plinest will usually last around 6-12 months. As your skin continues to age you may find a six monthly single treatment beneficial to maintain your skin results.

We advise booking your first single maintenance treatment 6 months from finishing your initial course of polynucleotides.